Erianin: A phytoestrogen with therapeutic potential

Front Pharmacol. 2023 Aug 7:14:1197056. doi: 10.3389/fphar.2023.1197056. eCollection 2023.


Erianin, a phytoestrogen with therapeutic potential, is one of the major active components of Dendrobll caulis. Erianin has a variety of pharmacological effects, such as anti-tumor, anti-inflammatory, anti-diabetic retinopathy, anti-psoriasis, and antibacterial effects. Especially, in regard to the anti-tumor effect of erianin, the underlying molecular mechanism has been partly clarified. In fact, the numerous pharmacological actions of erianin are complex and interrelated, mainly including ERK1/2, PI3K/Akt, JAK2/STAT3, HIF-1α/PD-L1, PPT1/mTOR, JNK/c-Jun, and p38 MAPK signal pathway. However, on account of the poor water solubility and the low bioavailability of erianin, greatly affected and limited its further development and application. And it is worthwhile and meaningful to explore more extensive pharmacological effects and mechanisms, clarify pharmacokinetics, and synthesize the derivatives of erianin. Conclusively, in this paper, the pharmacological effects of erianin and its mechanism, pharmacokinetics, and derivatives studies were reviewed, in order to provide a reference for the development and application of erianin.

Keywords: anti-tumour effect; derivatives; erianin; mechanism; pharmacokinetics.

Publication types

  • Review

Grants and funding

This study was supported by Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (No: ZYYCXTD-D-202209); Multidimensional evaluation of characteristic traditional Chinese medicine resources and product development innovation team (2022C001); the National Natural Science Foundation of China (no. 81891012); Study on Authenticity of Genuine Medicinal Materials in Sichuan (U19A2010).