Dual-Responsive Drug-Delivery System Based on PEG-Functionalized Pillararenes Containing Disulfide and Amido Bonds for Cancer Theranostics

Chembiochem. 2023 Nov 2;24(21):e202300513. doi: 10.1002/cbic.202300513. Epub 2023 Sep 8.

Abstract

The construction of a smart drug-delivery system based on amphiphilic pillararenes with multiple responsiveness properties has become an important way to improve the efficacy of tumor chemotherapy. Here, a new PEG-functionalized pillararene (EtP5-SS-PEG) containing disulfide and amido bonds was designed and synthesized, which has been used to construct a novel supramolecular nanocarrier through a host-guest interaction with a perylene diimide derivative (PDI-2NH4 ) and their supramolecular self-assembly. This nanocarrier showed good drug loading capability, and dual stimulus responsiveness to enzyme and GSH (glutathione). After loading of doxorubicin (DOX), the prepared nanodrugs displayed efficient DOX release and outstanding cancer theranostics ability.

Keywords: cancer theranostics; drug-delivery systems; enzyme responsiveness; host-guest interactions; pillararenes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Doxorubicin
  • Drug Delivery Systems
  • Glutathione
  • Humans
  • Micelles
  • Neoplasms* / drug therapy
  • Precision Medicine*

Substances

  • Doxorubicin
  • Micelles
  • Glutathione