Kinetics of cell kill by hyperthermia

Cancer Res. 1979 Jun;39(6 Pt 2):2277-84.


A review of published reports showed that there was surprisingly good agreement between different authors on the heat sensitivity of a particular cell line. For several cell lines, there was a marked difference in the heat of inactivation above 43 degrees (deltaH = 148 kcal/mol) and below 43 degrees (deltaH = 365 kcal/mol). This may indicate different mechanisms of cell killing above and below this temperature. With all cell lines tested, M- and S-phase cells were much more heat sensitive than were G1 or G2 cells. The heat sensitivity of S-phase cells is in contrast to the resistance of these cells to X-rays. The effect of hyperthermia on cell progression is discussed. The possibility of greater sensitivity of neoplastic cells to hyperthermia as compared to normal cells seems very promising.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage
  • Cell Cycle
  • Cell Line
  • Cell Survival* / drug effects
  • Cricetinae
  • Doxorubicin / administration & dosage
  • HeLa Cells
  • Hot Temperature / therapeutic use*
  • Kinetics
  • Leukemia L1210 / therapy
  • Mammary Neoplasms, Experimental / therapy
  • Mice
  • Neoplasms, Experimental / therapy*


  • Antineoplastic Agents
  • Doxorubicin