Lysophospholipid acyltransferases orchestrate the compositional diversity of phospholipids

Biochimie. 2023 Dec:215:24-33. doi: 10.1016/j.biochi.2023.08.012. Epub 2023 Aug 21.


Lysophospholipid acyltransferases (LPLATs), in concert with glycerol-3-phosphate acyltransferases (GPATs) and phospholipase A1/2s, orchestrate the compositional diversity of the fatty chains in membrane phospholipids. Fourteen LPLAT enzymes which come from two distinct families, AGPAT and MBOAT, have been identified, and in this mini-review we provide an overview of their roles in de novo and remodeling pathways of membrane phospholipid biosynthesis. Recently new nomenclature for LPLATs has been introduced (LPLATx, where x is a number 1-14), and we also give an overview of key biological functions that have been discovered for LPLAT1-14, revealed primarily through studies of LPLAT-gene-deficient mice as well as by linkages to various human diseases.

Keywords: Cellular membrane; Fatty acid; Glycerophospholipid; Lysophospholipid acyltransferase.

Publication types

  • Review

MeSH terms

  • 1-Acylglycerophosphocholine O-Acyltransferase* / genetics
  • 1-Acylglycerophosphocholine O-Acyltransferase* / metabolism
  • Acyltransferases / metabolism
  • Animals
  • Humans
  • Lysophospholipids
  • Mice
  • Phospholipids* / metabolism


  • 1-Acylglycerophosphocholine O-Acyltransferase
  • Phospholipids
  • Lysophospholipids
  • Acyltransferases