Interstitial Granulomatous Dermatitis as the Initial Manifestation of Granulomatosis with Polyangiitis

Cureus. 2023 Jul 22;15(7):e42293. doi: 10.7759/cureus.42293. eCollection 2023 Jul.

Abstract

Interstitial granulomatous dermatitis (IGD) is a rare dermatological disorder. It is most commonly associated with autoimmune disorders mainly lupus and rheumatoid arthritis. It has rarely been reported to present as a first manifestation of an underlying vasculitis. Here, we present a case of a 44-year-old woman who presented initially with a violaceous rash starting in her neck and trunk and extending to her limbs, but sparing the palms and soles. She was also found to have an acute kidney injury. A biopsy of the skin lesion confirmed the diagnosis of IGD, and a kidney biopsy showed findings consistent with granulomatosis with polyangiitis. To the best of our knowledge, this is the seventh reported case of IGD associated with systemic vasculitis.

Keywords: autoimmune disorders; glomerulonephritis; rash; renal failure; vasculitis.

Publication types

  • Case Reports