Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor

Nature. 1986 Oct;323(6087):411-6. doi: 10.1038/323411a0.


Cloning and sequence analysis of DNA complementary to porcine cerebral messenger RNA encoding the muscarinic acetylcholine receptor predict the complete amino-acid sequence of this protein. Expression of the complementary DNA produced functional muscarinic receptor in Xenopus oocytes. The muscarinic receptor is homologous with the beta-adrenergic receptor and rhodopsin in both amino-acid sequence and suggested transmembrane topography.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Brain / metabolism
  • Cloning, Molecular
  • DNA
  • Nucleic Acid Hybridization
  • Receptors, Cholinergic / genetics*
  • Swine
  • Xenopus


  • Receptors, Cholinergic
  • DNA

Associated data

  • GENBANK/X04413