Structure, sequence and expression of the hepatitis delta (delta) viral genome

Nature. 1986 Oct 9-15;323(6088):508-14. doi: 10.1038/323508a0.


Biochemical and electron microscopic data indicate that the human hepatitis delta viral agent contains a covalently closed circular and single-stranded RNA genome that has certain similarities with viroid-like agents from plants. The sequence of the viral genome (1,678 nucleotides) has been determined and an open reading frame within the complementary strand has been shown to encode an antigen that binds specifically to antisera from patients with chronic hepatitis delta viral infections.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Cloning, Molecular
  • DNA / genetics
  • Gene Expression Regulation
  • Genes
  • Genes, Viral
  • Hepatitis B Antigens / genetics*
  • Hepatitis Delta Virus / genetics*
  • Hepatitis delta Antigens
  • RNA, Viral / genetics


  • Hepatitis B Antigens
  • Hepatitis delta Antigens
  • RNA, Viral
  • hepatitis delta virus large antigen
  • DNA

Associated data

  • GENBANK/X04451