Clinical research progress on BRAF V600E-mutant advanced colorectal cancer

J Cancer Res Clin Oncol. 2023 Nov;149(17):16111-16121. doi: 10.1007/s00432-023-05301-0. Epub 2023 Aug 28.


Colorectal cancer is one of the malignant tumors that pose a serious threat to human health. A particularly bad prognosis might be expected for colorectal tumors with the unique molecular subtype BRAF V600E mutation. With the development of precision therapy, the advent of molecularly targeted therapies and immune checkpoint inhibitors has improved the outcome of intermediate to advanced colorectal cancer. However, the duration of drug benefit is usually short, and overall survival and progression-free survival remain suboptimal. Therefore, investigators are exploring more rational, safe, and effective drug combination regimens through clinical trials to provide longer survival for patients with such genetic mutations with metastatic colorectal cancer (mCRC). This article reviews the progress of clinical research on molecularly targeted drugs, immune checkpoint inhibitors, first-line chemotherapeutic agents, and different combination therapy regimens (including different targeted drug combinations, immune combination targeting, and chemotherapy combination targeting) for colorectal cancer patients with BRAF V600E mutation, which provides a reference for further in-depth clinical exploration of the treatment of colorectal cancer patients with BRAF V600E mutation.

Keywords: BRAF V600E mutation; Clinical research; Colorectal cancer; Review.

Publication types

  • Review

MeSH terms

  • Colorectal Neoplasms* / drug therapy
  • Colorectal Neoplasms* / genetics
  • Colorectal Neoplasms* / pathology
  • Humans
  • Immune Checkpoint Inhibitors / therapeutic use
  • Mutation
  • Prognosis
  • Proto-Oncogene Proteins B-raf* / genetics


  • Proto-Oncogene Proteins B-raf
  • Immune Checkpoint Inhibitors
  • BRAF protein, human