Natural uORF variation in plants

Jiangen Wang; Juhong Liu; Zilong Guo

doi:10.1016/j.tplants.2023.07.005

Natural uORF variation in plants

Trends Plant Sci. 2024 Mar;29(3):290-302. doi: 10.1016/j.tplants.2023.07.005. Epub 2023 Aug 26.

Authors

Jiangen Wang¹, Juhong Liu², Zilong Guo³

Affiliations

¹ Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
² Fuzhou Institute for Data Technology Co., Ltd., Fuzhou 350207, China.
³ Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Electronic address: zlguo@fafu.edu.cn.

PMID: 37640640
DOI: 10.1016/j.tplants.2023.07.005

Abstract

Taking advantage of natural variation promotes our understanding of phenotypic diversity and trait evolution, ultimately accelerating plant breeding, in which the identification of causal variations is critical. To date, sequence variations in the coding region and transcription level polymorphisms caused by variations in the promoter have been prioritized. An upstream open reading frame (uORF) in the 5' untranslated region (5' UTR) regulates gene expression at the post-transcription or translation level. In recent years, studies have demonstrated that natural uORF variations shape phenotypic diversity. This opinion article highlights recent researches and speculates on future directions for natural uORF variation in plants.

Keywords: natural variation; phenotypic diversity; translational regulation; uORF.

Publication types

Review

MeSH terms

5' Untranslated Regions / genetics
Open Reading Frames / genetics
Plant Breeding*
Plants / genetics
Protein Biosynthesis*

Substances

5' Untranslated Regions