Primordial Odontogenic Tumor; Archival Review of 19380 Cases in a 55-Year Retrospective Study

Asian Pac J Cancer Prev. 2023 Aug 1;24(8):2845-2853. doi: 10.31557/APJCP.2023.24.8.2845.


Background and objective: Primordial odontogenic tumor is a rare odontogenic tumor reported for the first time in 2014. It was included in the latest edition of World Health Organization classification of Head and Neck Tumors as a new benign mixed epithelial-mesenchymal neoplasm. To date, 26 cases has been reported in literature. The aim of this study was to determine the possible presence of primordial odontogenic tumor in the previously diagnosed cases with myxoid stroma.

Materials and methods: This study was a retrospective descriptive study that was concluded in Oral and Maxillofacial Pathology Department, School of Dentistry, Tehran University of Medical Sciences. We reviewed all 19,380 cases from 19,66 to find the lesions with myxoid stroma which were in differential diagnosis with primordial odontogenic tumor. These cases should be associated with an impacted or unerupted tooth and belong to the patients under 20 years old.

Results: We find 503 pericoronal lesions with myxoid stroma. Three cases were isolated after recut and reevaluation for finding fulfill histologic features. After immunohistochemical analysis, we find a new case of developing primordial odontogenic tumor associated with odontoma.

Discussion: Primordial odontogenic tumor a recently described odontogenic tumor has a well-defined clinicopathological and immunohistochemical profile and should be differentiated from the others pericoronal lesions. It is the first time that this archival review has been done to find probable cases of primordial odontogenic tumor.

Keywords: Odontogenic; Primordial; Tumor; neoplasm.

Publication types

  • Review

MeSH terms

  • Adult
  • Diagnosis, Differential
  • Humans
  • Iran
  • Neoplasms, Glandular and Epithelial*
  • Odontogenic Tumors*
  • Retrospective Studies
  • Young Adult