Transmembrane Transporter Constructed from PlatinumMetal-organic Cage

Chempluschem. 2023 Sep;88(9):e202300426. doi: 10.1002/cplu.202300426.


A perylene diimide-based metal-organic cage (MOC4c) was found to be an efficient transmembrane transporter for ions and small molecules through the internal cavity of the cage. MOC4c could selectively transport different anions, as evidenced by vesicle-based fluorescenceassays and planar lipid bilayer-based current recordings.Furthermore, MOC4c appears tofacilitate calcein transport across the lipid bilayer membrane of a livingcell, suggesting that MOC4c could be used as a biologicaltool for small molecule drugstransmembrane transportation.

Keywords: host-guest chemistry; metal-organic cages; perylene diimides; supramolecular chemistry; transmembrane transporters.