All the PNS is a Stage: Transplanted Bone Marrow Cells Play an Immunomodulatory Role in Peripheral Nerve Regeneration

Gonzalo Piñero; Marianela Vence; Marcos L Aranda; Magalí C Cercato; Paula A Soto; Vanina Usach; Patricia C Setton-Avruj

doi:10.1177/17590914231167281

All the PNS is a Stage: Transplanted Bone Marrow Cells Play an Immunomodulatory Role in Peripheral Nerve Regeneration

ASN Neuro. 2023 Jan-Dec:15:17590914231167281. doi: 10.1177/17590914231167281.

Authors

Gonzalo Piñero^{1

2

3}, Marianela Vence², Marcos L Aranda^{4

5}, Magalí C Cercato², Paula A Soto^{1

2}, Vanina Usach^{1

2}, Patricia C Setton-Avruj^{1

2}

Affiliations

¹ Departamento de Química Biológica, Cátedra de Química Biológica Patalógica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.
² Universidad de Buenos Aires-CONICET, Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Ciudad Autónoma de Buenos Aires, Argentina.
³ Department of Pathology, Mount Sinai Hospital, New York, NY, USA.
⁴ Universidad de Buenos Aires-CONICET, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Ciudad Autónoma de Buenos Aires, Argentina.
⁵ Department of Neurobiology, Weinberg College of Arts and Sciences, Northwestern University, Evanston, IL, USA.

Abstract

Bone marrow cell transplant has proven to be an effective therapeutic approach to treat peripheral nervous system injuries as it not only promoted regeneration and remyelination of the injured nerve but also had a potent effect on neuropathic pain.

Keywords: Wallerian degeneration; bone marrow cells; immunomodulation; remyelination.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Axons*
Bone Marrow Cells
Nerve Regeneration / physiology
Peripheral Nervous System
Remyelination* / physiology