The HLA advantage: Why COVID-19 benched you but not your co-worker

Sci Immunol. 2023 Sep;8(87):eadk5067. doi: 10.1126/sciimmunol.adk5067. Epub 2023 Sep 1.

Authors

Nisha Saif¹, Gabriel K Griffin^{1

2}

Affiliations

¹ Broad Institute of MIT and Harvard, Cambridge, MA, USA.
² Dana-Farber Cancer Institute, Boston, MA, USA.

PMID: 37656777
DOI: 10.1126/sciimmunol.adk5067

Abstract

An HLA variant confers protective immunity against COVID-19 through cross-reactive T cells induced by seasonal coronaviruses.

MeSH terms

COVID-19* / immunology
Cross Reactions / immunology
HLA Antigens* / genetics
HLA Antigens* / immunology
Humans
SARS-CoV-2* / immunology
T-Lymphocytes / immunology

Substances

HLA Antigens