Impact of tracheostomies on the long-term survival of patients with trisomy 13 syndrome

Shoko Tamaki; Sota Iwatani; Shinji Hagimoto; Ayako Izumi; Toshihiko Ikuta; Emiko Takeoka; Sachiko Matsui; Hitomi Mimura; Shogo Minamikawa; Yasuo Nakagishi; Seiji Yoshimoto; Hideto Nakao

doi:10.1002/ajmg.a.63393

Impact of tracheostomies on the long-term survival of patients with trisomy 13 syndrome

Am J Med Genet A. 2023 Nov;191(11):2736-2742. doi: 10.1002/ajmg.a.63393. Epub 2023 Sep 1.

Authors

Affiliations

¹ Department of Neonatology, Hyogo Prefectural Kobe Children's Hospital Perinatal Center, Kobe, Japan.
² Department of Pediatrics, Tottori Prefectural Central Hospital, Tottori, Japan.
³ Department of General Pediatrics, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan.

PMID: 37658587
DOI: 10.1002/ajmg.a.63393

Abstract

In this retrospective cohort study, we investigated the impact of tracheostomies on the long-term survival of children with trisomy 13 syndrome at a Japanese tertiary pediatric center. We compared survival and survival to discharge rates between patients who underwent tracheostomies during their NICU stays (T group, n = 8) and those who did not (non-T group, n = 11). A total of 19 patients enrolled. Median survival in all patients was 673 (266-1535) days. Significant differences in the 1-, 2-, and 3-year survival rates were found between the T and the non-T groups (100% vs. 46%, p = 0.018; 88% vs. 18%, p = 0.006; 63% vs. 9%, p = 0.041, respectively). The survival to discharge rate was higher in the T versus non-T group (75% vs. 45%, p = 0.352). This study highlights a significantly higher long-term survival of patients with trisomy 13 syndrome who underwent tracheostomies during their NICU stays.

Keywords: intensive care; neonatal intensive care unit; surgery; survival to discharge.