Urinary and fecal excretions and absorption of a large supplement of selenium: superiority of selenate over selenite

Am J Clin Nutr. 1986 Nov;44(5):659-63. doi: 10.1093/ajcn/44.5.659.

Abstract

A correction needs to be made to the form of selenium used in earlier studies; what was believed to be selenite-Se in solution is now known to have been selenate-Se. In the present study, excretion of Se was followed in 13 women after ingestion of 1 mg Se as selenite or selenate in solution. Fecal excretion of selenate-Se was less than for selenite-Se reflecting a higher apparent absorption [94 +/- 4% (SD), 62 +/- 14%, respectively]. Peak excretion of Se occurred 3 h earlier for selenate-Se than for selenite-Se and was 6 times higher. Total urinary excretion of selenate-Se was 3 times that of selenite-Se and still 2 times as high when expressed as % absorbed dose. Total recovery of Se in urine and feces was similar for both forms. There was remarkable agreement between these results and those reported earlier for selenate-Se (Selovet-1) and selenite-Se.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biological Availability
  • Feces / analysis
  • Female
  • Humans
  • Intestinal Absorption
  • Selenic Acid
  • Selenious Acid
  • Selenium / metabolism*
  • Selenium / urine
  • Selenium Compounds*

Substances

  • Selenium Compounds
  • Selenious Acid
  • Selenium
  • Selenic Acid