Role of Th17 and IL-17 Cytokines on Inflammatory and Auto-immune Diseases

Saima Akhter; Farhin Muntaha Tasnim; Mohammad Nazmul Islam; Abdur Rauf; Saikat Mitra; Talha Bin Emran; Fahad A Alhumaydhi; Anees Ahmed Khalil; Abdullah S M Aljohani; Waleed Al Abdulmonem; Muthu Thiruvengadam

doi:10.2174/1381612829666230904150808

Role of Th17 and IL-17 Cytokines on Inflammatory and Auto-immune Diseases

Curr Pharm Des. 2023;29(26):2078-2090. doi: 10.2174/1381612829666230904150808.

Affiliations

¹ Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh.
² Department of Chemistry, University of Swabi, Swabi, Pakistan.
³ Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh.
⁴ Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh.
⁵ Department of Medical Laboratories, College of Applied Medical Science, Qassim University, Buraydah, Saudi Arabia.
⁶ University Institute of Diet and Nutritionals Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan.
⁷ Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah, Saudi Arabia.
⁸ Department of Pathology, College of Medicine, Qassim University, Buraydah, Saudi Arabia.
⁹ Department of Crop Science, College of Sanghuh Life Science, Konkuk University, Seoul 05029, Republic of Korea.

PMID: 37670700
DOI: 10.2174/1381612829666230904150808

Abstract

Background: The IL-17 (interleukin 17) family consists of six structurally related pro-inflammatory cytokines, namely IL-17A to IL-17F. These cytokines have garnered significant scientific interest due to their pivotal role in the pathogenesis of various diseases. Notably, a specific subset of T-cells expresses IL-17 family members, highlighting their importance in immune responses against microbial infections.

Introduction: IL-17 cytokines play a critical role in host defense mechanisms by inducing cytokines and chemokines, recruiting neutrophils, modifying T-cell differentiation, and stimulating the production of antimicrobial proteins. Maintaining an appropriate balance of IL-17 is vital for overall health. However, dysregulated production of IL-17A and other members can lead to the pathogenesis of numerous inflammatory and autoimmune diseases.

Method: This review provides a comprehensive overview of the IL-17 family and its involvement in several inflammatory and autoimmune diseases. Relevant literature and research studies were analyzed to compile the data presented in this review.

Results: IL-17 cytokines, particularly IL-17A, have been implicated in the development of various inflammatory and autoimmune disorders, including multiple sclerosis, Hashimoto's thyroiditis, systemic lupus erythematosus, pyoderma gangrenosum, autoimmune hepatic disorders, rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, osteoarthritis, and graft-versus-host disease. Understanding the role of IL-17 in these diseases is crucial for developing targeted therapeutic strategies.

Conclusion: The significant involvement of IL-17 cytokines in inflammatory and autoimmune diseases underscores their potential as therapeutic targets. Current treatments utilizing antibodies against IL-17 cytokines and IL-17RA receptors have shown promise in managing these conditions. This review consolidates the understanding of IL-17 family members and their roles, providing valuable insights for the development of novel immunomodulators to effectively treat inflammatory and autoimmune diseases.

Keywords: CD4⁺; IL-17; T cell; Th17; autoimmune disease; cytokines..

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Arthritis, Rheumatoid*
Autoimmune Diseases* / drug therapy
Cytokines / metabolism
Humans
Interleukin-17 / metabolism
Th17 Cells / metabolism

Substances

Interleukin-17
Cytokines