This is the first study on the effects of a prebiotic diet on the oral mucosal bacterial microbiome and an oropharyngeal candidiasis (OPC) mouse model. We found that xylo-oligosaccharides change the oral bacterial community composition and attenuate OPC. Our results contribute to the understanding of the impact of the oral bacterial communities on Candida virulence.
Keywords: Candida albicans; Lactobacillus; candidiasis; dysbiosis; fungal infection; oral microbiome; prebiotic; xylooligosaccharides.