SIRPα: A key player in innate immunity

Eur J Immunol. 2023 Nov;53(11):e2350375. doi: 10.1002/eji.202350375. Epub 2023 Sep 17.


Signal regulatory protein alpha (SIRPα) is a crucial inhibitory regulator expressed on the surface of myeloid cells, including macrophages, dendritic cells, monocytes, neutrophils, and microglia. SIRPα plays an indispensable role in innate immune and adoptive immune responses in cancer immunology, tissue homeostasis, and other physiological or phycological conditions. This review provides an overview of the research history, ligands, signal transduction pathways, and functional mechanisms associated with SIRPα. Additionally, we summarize the therapeutic implications of targeting SIRPα as a promising novel strategy in immuno-oncology.

Keywords: CD47; Cancer immunology; Diseases; Innate immunity; SIRPα.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Differentiation
  • Humans
  • Immunity, Innate
  • Macrophages
  • Myeloid Cells / metabolism
  • Neoplasms*
  • Phagocytosis*


  • Antigens, Differentiation