[Prognosis of hemolytic uremic syndrome in children. Importance of extrarenal involvement]

Arch Fr Pediatr. 1986 Apr;43(4):253-8.
[Article in French]


The prognosis of hemolytic uremic syndrome was studied in 37 children hospitalized between January 1980 and January 1985. 75% of affected children were less than 3 years of age. Twenty-two (60%) presented with anuria or oliguria (mean duration of anuria: 10.7 days). In this last group, severe extrarenal manifestations occurred: 12 cases of neurological involvement (6 involving hypervolemia), gastrointestinal involvement in 5 cases, including a case of ileal necrosis; pancreatic involvement in another. Three children died during the first month of the disease (overall death-rate: 8%). Thirty-two children were followed with a mean 24 months follow-up (6 months to 60 months). Six (19%) presented with sequellae, of which 3 were severe: one severe arterial hypertension and two with chronic renal failure of which one terminal with severe neurologic sequellae. The existence of extrarenal manifestations implies a poor prognosis. Among the 22 children with anuria or oliguria, 8 had no extra-renal manifestations. All of these recovered. Three of 11 children with one extrarenal manifestation had an unfavorable outcome. The course was unfavorable in the 3 cases with multiple extrarenal involvement.

Publication types

  • English Abstract

MeSH terms

  • Anuria / etiology
  • Child
  • Child, Preschool
  • Coma / etiology
  • Digestive System Diseases / etiology
  • Female
  • Hemolytic-Uremic Syndrome / complications*
  • Hemolytic-Uremic Syndrome / pathology
  • Hemolytic-Uremic Syndrome / physiopathology
  • Humans
  • Hypertension / etiology
  • Infant
  • Kidney Diseases / etiology
  • Male
  • Pancreatic Diseases / etiology
  • Prognosis
  • Retrospective Studies
  • Seizures / etiology