The separate axes of TECPR1 and ATG16L1 in CASM

Autophagy. 2023 Sep 7;1-2. doi: 10.1080/15548627.2023.2255462. Online ahead of print.


Conjugation of ATG8 to single membranes (CASM) is a fundamental cellular process that entails the conjugation of mammalian Atg8 homologs, here referred to as ATG8, to phosphatidylethanolamine (PE) and phosphatidylserine (PS) on endolysosomal compartments. Our current research, together with recent reports from the Randow, Wu, and Wileman labs, has uncovered yet another layer to this process. We discovered that, in addition to ATG16L1-containing complexes, TECPR1 (tectonin beta-propeller repeat containing 1)-containing ATG12-ATG5 E3 complexes can facilitate CASM, thereby providing a broader understanding of this pathway.

Keywords: CASM; DysF; SopF; membrane damage; non-canonical autophagy; sphingomyelin.