Mutational landscape and predictors of survival in head and neck mucosal melanoma

Brandon M Lehrich; Arash Abiri; Theodore V Nguyen; Benjamin F Bitner; Charles C L Tong; Edward C Kuan

doi:10.1002/alr.23267

Mutational landscape and predictors of survival in head and neck mucosal melanoma

Int Forum Allergy Rhinol. 2024 Apr;14(4):858-861. doi: 10.1002/alr.23267. Epub 2023 Sep 7.

Authors

Brandon M Lehrich^{1

2}, Arash Abiri^{3

4}, Theodore V Nguyen⁴, Benjamin F Bitner⁴, Charles C L Tong⁵, Edward C Kuan^{4

6}

Affiliations

¹ Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
² Medical Scientist Training Program, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
³ Medical Scientist Training Program, University of California, Irvine, California, USA.
⁴ Department of Otolaryngology, University of California, Irvine, California, USA.
⁵ Department of Otolaryngology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, New York, USA.
⁶ Department of Neurological Surgery, University of California, Irvine, California, USA.

PMID: 37676479
PMCID: PMC10918024 (available on 2025-04-01)
DOI: 10.1002/alr.23267

Abstract

Head and neck mucosal melanomas have a diverse mutational landscape with low mutational burden. A molecular subset (∼13%) has ROS1 mutations, which is an actionable driver mutation. ROS1-mutated patients have improved overall survival likely due to high mutational burden.

Keywords: mucosal melanoma; patient survival; tumor genetics; tumor mutational burden.

MeSH terms

DNA Mutational Analysis
Humans
Melanoma* / genetics
Mutation
Protein-Tyrosine Kinases / genetics
Proto-Oncogene Proteins / genetics

Substances

Protein-Tyrosine Kinases
Proto-Oncogene Proteins

Abstract

MeSH terms

Substances

Grants and funding