Effect and mechanism of microRNAs on various diabetic wound local cells

J Diabetes. 2023 Nov;15(11):955-967. doi: 10.1111/1753-0407.13474. Epub 2023 Sep 7.

Abstract

The difficulty of wound healing in diabetes mellitus has long been regarded as a thorny problem in the medical field. One of the important reasons is the abnormal function of wound-related cells. A large number of recent studies have shown that microRNA (miR), a noncoding RNA that exists in eukaryotic cells, is closely linked to the functions of various cells in diabetic wound, and ultimately affects the healing of wound. This paper establishes for the first time the connection between miR and wound healing from the cellular perspective and summarizes the effects of various miRs on one or more kinds of wound cells, including their targets and related mechanisms. The abnormal expression of miRs in the wound has certain value for the early diagnosis of diabetic wounds. Moreover, it seems that correcting miRs that are abnormal expressed in the wound or artificially adding miRs that can promote wound healing has an essential therapeutic value.

糖尿病创面愈合困难一直被认为是医学界的棘手问题。创面相关细胞功能异常是其重要原因之一。最近大量研究表明,microRNA (miR)是一种存在于真核细胞中的非编码RNA,与糖尿病创面中各种细胞的功能密切相关,并最终影响创面的愈合。本文从细胞角度建立miR与创面愈合之间的联系,并总结了各种miR对一种或多种创面细胞的作用,包括其作用靶点和相关机制。创面中miR的异常表达对糖尿病创面的早期诊断具有一定价值。此外,纠正创面中异常表达的miR或人为添加可促进创面愈合的miR似乎具有重要的治疗价值。.

Keywords: diabetic wound; local wound cell; microRNA; wound healing; 伤口愈合; 局部伤口细胞; 糖尿病伤口.

Publication types

  • Review

MeSH terms

  • Diabetes Mellitus*
  • Humans
  • MicroRNAs* / genetics
  • Wound Healing / genetics

Substances

  • MicroRNAs