Theophylline pharmacokinetics after intravenous infusion with ethylenediamine or sodium glycinate

Br J Clin Pharmacol. 1986 Sep;22(3):351-5. doi: 10.1111/j.1365-2125.1986.tb02899.x.

Abstract

Six healthy volunteers received two theophylline preparations by short intravenous infusion, at weekly intervals in a randomized cross-over design. The solubilizer was ethylenediamine or sodium glycinate. Plasma concentrations of theophylline and ethylenediamine were measured by h.p.l.c. for up to 24 h after dosing. The pharmacokinetics of theophylline did not show any significant intra-subject variation associated with the solubilizing agent used.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Drug Compounding
  • Ethylenediamines / metabolism
  • Ethylenediamines / pharmacology*
  • Female
  • Glycine / metabolism*
  • Humans
  • Infusions, Intravenous
  • Kinetics
  • Male
  • Middle Aged
  • Pharmaceutic Aids / metabolism
  • Pharmaceutic Aids / pharmacology*
  • Solubility
  • Theophylline / administration & dosage
  • Theophylline / metabolism*

Substances

  • Ethylenediamines
  • Pharmaceutic Aids
  • Theophylline
  • Glycine