Abstract
Six healthy volunteers received two theophylline preparations by short intravenous infusion, at weekly intervals in a randomized cross-over design. The solubilizer was ethylenediamine or sodium glycinate. Plasma concentrations of theophylline and ethylenediamine were measured by h.p.l.c. for up to 24 h after dosing. The pharmacokinetics of theophylline did not show any significant intra-subject variation associated with the solubilizing agent used.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Drug Compounding
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Ethylenediamines / metabolism
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Ethylenediamines / pharmacology*
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Female
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Glycine / metabolism*
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Humans
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Infusions, Intravenous
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Kinetics
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Male
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Middle Aged
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Pharmaceutic Aids / metabolism
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Pharmaceutic Aids / pharmacology*
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Solubility
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Theophylline / administration & dosage
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Theophylline / metabolism*
Substances
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Ethylenediamines
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Pharmaceutic Aids
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Theophylline
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Glycine