Lateralization of the cerebral network of inhibition in children before and after cognitive training

Dev Cogn Neurosci. 2023 Oct:63:101293. doi: 10.1016/j.dcn.2023.101293. Epub 2023 Sep 3.


Inhibitory control (IC) plays a critical role in cognitive and socio-emotional development. IC relies on a lateralized cortico-subcortical brain network including the inferior frontal cortex, anterior parts of insula, anterior cingulate cortex, caudate nucleus and putamen. Brain asymmetries play a critical role for IC efficiency. In parallel to age-related changes, IC can be improved following training. The aim of this study was to (1) assess the lateralization of IC network in children (N = 60, 9-10 y.o.) and (2) examine possible changes in neural asymmetry of this network from anatomical (structural MRI) and functional (resting-state fMRI) levels after 5-week computerized IC vs. active control (AC) training. We observed that IC training, but not AC training, led to a leftward lateralization of the putamen anatomy, similarly to what is observed in adults, supporting that training could accelerate the maturation of this structure.

Keywords: Anatomical MRI; Brain lateralization; Brain maturation; Functional MRI; Inhibition; Training.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain Mapping
  • Brain* / physiology
  • Cerebral Cortex / physiology
  • Child
  • Cognitive Training*
  • Frontal Lobe
  • Gyrus Cinguli
  • Humans
  • Magnetic Resonance Imaging