Ebolavirus VP40 redux. Or rather, redox

Structure. 2023 Sep 7;31(9):1008-1010. doi: 10.1016/j.str.2023.08.010.


The virion protein 40 (VP40) forms the viral matrix, mediates budding, and downregulates viral RNA synthesis in ebolaviruses. In this issue of Structure, Werner et al. present a structure of VP40 from Sudan ebolavirus with a previously unresolved disulfide bridge that enables regulation of VP40 functions via human thioredoxin.

MeSH terms

  • Cell Division
  • Disulfides
  • Ebolavirus* / genetics
  • Humans
  • Oxidation-Reduction
  • Virion


  • Disulfides