HLA alleles: important pieces to the COVID-19 puzzle

Patricia Castro-Santos; Ángel Carracedo; Roberto Díaz-Peña

doi:10.1016/j.it.2023.08.011

HLA alleles: important pieces to the COVID-19 puzzle

Trends Immunol. 2023 Oct;44(10):754-756. doi: 10.1016/j.it.2023.08.011. Epub 2023 Sep 9.

Authors

Patricia Castro-Santos¹, Ángel Carracedo², Roberto Díaz-Peña³

Affiliations

¹ Fundación Pública Galega de Medicina Xenómica (SERGAS). Centro Nacional de Genotipado. Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain; Faculty of Health Sciences, Universidad Autónoma de Chile, Talca, Chile.
² Fundación Pública Galega de Medicina Xenómica (SERGAS). Centro Nacional de Genotipado. Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain; Grupo de Medicina Xenómica- CIMUS- Universidade de Santiago de Compostela, Santiago de Compostela, Spain; Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.
³ Fundación Pública Galega de Medicina Xenómica (SERGAS). Centro Nacional de Genotipado. Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain; Faculty of Health Sciences, Universidad Autónoma de Chile, Talca, Chile. Electronic address: roberto.diaz.pena@sergas.es.

PMID: 37690961
DOI: 10.1016/j.it.2023.08.011

Abstract

Research on human leukocyte antigen (HLA) molecules in coronavirus disease 2019 (COVID-19) raised high expectations but has yielded limited results. Augusto et al.'s recent study in Nature unveils a strong association of HLA-B*15:01 with asymptomatic COVID-19, representing an important contribution to genetics in COVID-19.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
COVID-19* / genetics
HLA Antigens / genetics
HLA-B Antigens / genetics
Histocompatibility Antigens Class I / genetics
Humans

Substances

Histocompatibility Antigens Class I
HLA Antigens
HLA-B Antigens