Background and roles: myosin in autoimmune diseases

Front Cell Dev Biol. 2023 Aug 23:11:1220672. doi: 10.3389/fcell.2023.1220672. eCollection 2023.


The myosin superfamily is a group of molecular motors. Autoimmune diseases are characterized by dysregulation or deficiency of the immune tolerance mechanism, resulting in an immune response to the human body itself. The link between myosin and autoimmune diseases is much more complex than scientists had hoped. Myosin itself immunization can induce experimental autoimmune diseases of animals, and myosins were abnormally expressed in a number of autoimmune diseases. Additionally, myosin takes part in the pathological process of multiple sclerosis, Alzheimer's disease, Parkinson's disease, autoimmune myocarditis, myositis, hemopathy, inclusion body diseases, etc. However, research on myosin and its involvement in the occurrence and development of diseases is still in its infancy, and the underlying pathological mechanisms are not well understood. We can reasonably predict that myosin might play a role in new treatments of autoimmune diseases.

Keywords: Alzheimer; NMMHC IIA; Parkinson; autoimmune; autoimmune myocardioptis; multiple sclerosis; myosin.

Publication types

  • Review

Grants and funding

This work was supported by the Foundation Project: National Natural Science Foundation of China (Nos 82100417 and 81760094); The Foundation of Jiangxi Provincial Department of Science and Technology Youth Key Project (Nos 20202ACBL206001 and 20212BAB206022); Youth Project of Jiangxi Provincial Department of Education (No. GJJ200217). All funding bodies had no role in the design of the study and collection, analysis, and interpretation of the data or in writing the manuscript.