The Pho23-Rpd3 histone deacetylase complex regulates the yeast metabolic transcription factor Stb5

Elizabeth Delorme-Axford; Tabassum Ahmad Tasmi; Daniel J Klionsky

doi:10.17912/micropub.biology.000940

The Pho23-Rpd3 histone deacetylase complex regulates the yeast metabolic transcription factor Stb5

MicroPubl Biol. 2023 Aug 25:2023:10.17912/micropub.biology.000940. doi: 10.17912/micropub.biology.000940. eCollection 2023.

Authors

Elizabeth Delorme-Axford¹, Tabassum Ahmad Tasmi¹, Daniel J Klionsky²

Affiliations

¹ Biological Sciences, Oakland University, Rochester, Michigan, United States.
² Life Sciences Institute and Department of Molecular, Cellular, and Developmental Biology, University of Michigan-Ann Arbor, Ann Arbor, Michigan, United States.

Abstract

Macroautophagy/autophagy is an essential catabolic process for maintaining homeostasis and cell survival under stressful conditions. We previously characterized the metabolic transcription factor Stb5 as a negative modulator of autophagy through its regulation of genes involved in NADPH production. However, the molecular mechanisms regulating STB5 expression are not fully characterized. Here, we identify the yeast Pho23-Rpd3 histone deacetylase complex as a transcriptional regulator of STB5 . Our work provides insight into the mechanisms modulating the metabolic transcription factor Stb5 and expands on the repertoire of genes targeted by the Pho23-Rpd3 complex.

Grants and funding

This work was supported by Oakland University startup funds (to EDA) and NIH grant GM131919 (to DJK). TAT was supported by a graduate teaching assistantship obtained through the Department of Biological Sciences at Oakland University.