Major antigenic groups of rabies virus in Canada determined by anti-nucleocapsid monoclonal antibodies

Comp Immunol Microbiol Infect Dis. 1986;9(1):59-69. doi: 10.1016/0147-9571(86)90076-7.


A total of 123 rabies virus isolates from various geographical areas in Canada were characterized by a panel of 43 anti-nucleocapsid monoclonal antibodies. Four major antigenic groups are found in terrestrial mammals: "Canadian Arctic" from Ontario, Quebec and the Northwest Territories; "south-eastern Georgian Bay" from Ontario; "south mid-central skunk" from Alberta, Saskatchewan and Manitoba; and "Brook's, Alberta skunk" from a restricted area in Alberta. Bat isolates can be divided into 4 major antigenic groups: "B-1" in Eptesicus fuscus from Ontario; "B-2" in a variety of bat species from British Columbia eastward into Ontario; "B-3" in Myotis spp. from Ontario and New Brunswick; and "B-4" in E. fuscus from Alberta and Saskatchewan. A single case of bat to horse transmission of rabies virus is recorded. These street isolates are compared with isolates of fixed virus. Epidemiological aspects are discussed.

MeSH terms

  • Animals
  • Animals, Domestic
  • Animals, Wild
  • Antibodies, Monoclonal
  • Antigens, Viral / analysis*
  • Canada
  • Capsid / analysis*
  • Cats
  • Demography
  • Dogs
  • Foxes
  • Horses
  • Mephitidae
  • Rabies / veterinary
  • Rabies virus / isolation & purification*
  • Rats
  • Viral Core Proteins / analysis*


  • Antibodies, Monoclonal
  • Antigens, Viral
  • Viral Core Proteins