From materials to clinical use: advances in 3D-printed scaffolds for cartilage tissue engineering

Phys Chem Chem Phys. 2023 Sep 20;25(36):24244-24263. doi: 10.1039/d3cp00921a.

Abstract

Osteoarthritis caused by articular cartilage defects is a particularly common orthopedic disease that can involve the entire joint, causing great pain to its sufferers. A global patient population of approximately 250 million people has an increasing demand for new therapies with excellent results, and tissue engineering scaffolds have been proposed as a potential strategy for the repair and reconstruction of cartilage defects. The precise control and high flexibility of 3D printing provide a platform for subversive innovation. In this perspective, cartilage tissue engineering (CTE) scaffolds manufactured using different biomaterials are summarized from the perspective of 3D printing strategies, the bionic structure strategies and special functional designs are classified and discussed, and the advantages and limitations of these CTE scaffold preparation strategies are analyzed in detail. Finally, the application prospect and challenges of 3D printed CTE scaffolds are discussed, providing enlightening insights for their current research.

Publication types

  • Review

MeSH terms

  • Biocompatible Materials
  • Cartilage*
  • Humans
  • Printing, Three-Dimensional
  • Tissue Engineering*

Substances

  • Biocompatible Materials