Impaired DNA-repair synthesis in lymphocytes of breast cancer patients

Eur J Cancer Clin Oncol. 1986 Jul;22(7):863-9. doi: 10.1016/0277-5379(86)90375-5.

Abstract

UV-C light induced DNA-repair synthesis was studied in unstimulated lymphocytes of 41 female patients (aged 33-83 years) with invasive breast cancer and of 27 healthy women (aged 37-68 years). As a parameter for the determination of the DNA-repair synthesis the incorporation of [3H] thymidine was taken in the presence of 2 mM hydroxyurea (HU). The [3H] thymidine incorporation levels were reduced in 20 of the 41 patients and in only 3 of the 27 controls. This difference between the two groups was significant. An impaired DNA-repair synthesis might be involved in the etiology of breast cancer in some patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Breast Neoplasms / metabolism*
  • Breast Neoplasms / radiotherapy
  • Breast Neoplasms / surgery
  • DNA / biosynthesis
  • DNA Repair*
  • Female
  • Humans
  • Hydroxyurea / pharmacology
  • Lymphocytes / metabolism*
  • Lymphocytes / radiation effects
  • Middle Aged
  • Thymidine / metabolism
  • Ultraviolet Rays

Substances

  • DNA
  • Thymidine
  • Hydroxyurea