Measurement of theophylline absorption from different regions of the gastro-intestinal tract using a remote controlled drug delivery device

Eur J Clin Pharmacol. 1986;30(6):691-7. doi: 10.1007/BF00608217.


The absorption of a theophylline solution containing 80-120 mg doses delivered to different sites in the gastro-intestinal tract has been determined in 3 male volunteers using a remote controlled drug release system (HF-capsule). There was no difference between the stomach, ileum and the colon in the amount of theophylline absorbed (AUC). The T 1/2abs of theophylline absorbed via the colon was prolonged when compared with that entering via the upper gastro-intestinal tract. The results provide a rational basis for the further development of theophylline formulations and are indispensable for planned development and to account for variation in the bioavailability of retarded release drug preparations.

MeSH terms

  • Absorption
  • Administration, Oral
  • Adult
  • Biological Availability
  • Capsules
  • Colon / metabolism
  • Digestive System / metabolism*
  • Dose-Response Relationship, Drug
  • Drug Administration Routes
  • Gastric Mucosa / metabolism
  • Humans
  • Ileum / metabolism
  • Kinetics
  • Male
  • Middle Aged
  • Theophylline / administration & dosage
  • Theophylline / metabolism*


  • Capsules
  • Theophylline