cDNA sequence of human beta-preprotachykinin, the common precursor to substance P and neurokinin A

FEBS Lett. 1986 Nov 10;208(1):67-72. doi: 10.1016/0014-5793(86)81534-4.


The nucleotide sequence of cDNA encoding the human substance P precursor, beta-preprotachykinin (beta-PPT), has been determined. The source of mRNA was a human laryngeal carcinoid tumour that contained a high concentration of immunoreactive substance P. The human beta-PPT polypeptide is 129 amino acids long and contains regions encoding substance P and neurokinin A, each flanked by basic amino acid residues. Residues 72-107 of the human beta-PPT polypeptide encode the sequence of neuropeptide K, an N-terminally extended form of neurokinin A recently isolated from porcine brain.

MeSH terms

  • Animals
  • Base Sequence
  • Cattle
  • Cloning, Molecular
  • DNA*
  • Humans
  • Neuropeptides / genetics*
  • Plasmids
  • Protein Precursors / genetics*
  • RNA, Messenger
  • Species Specificity
  • Tachykinins*


  • Neuropeptides
  • Protein Precursors
  • RNA, Messenger
  • Tachykinins
  • preprotachykinin
  • DNA