Predictive Modeling Using Artificial Intelligence and Machine Learning Algorithms on Electronic Health Record Data: Advantages and Challenges

Crit Care Clin. 2023 Oct;39(4):647-673. doi: 10.1016/j.ccc.2023.02.001. Epub 2023 Apr 26.


The rapid adoption of electronic health record (EHR) systems in US hospitals from 2008 to 2014 produced novel data elements for analysis. Concurrent innovations in computing architecture and machine learning (ML) algorithms have made rapid consumption of health data feasible and a powerful engine for clinical innovation. In critical care research, the net convergence of these trends has resulted in an exponential increase in outcome prediction research. In the following article, we explore the history of outcome prediction in the intensive care unit (ICU), the growing use of EHR data, and the rise of artificial intelligence and ML (AI) in critical care.

Keywords: Clinical informatics; Critical care outcome prediction; Data science; Electronic medical record analysis; Machine learning; Model performance evaluation; Mortality prediction; Sepsis prediction.

Publication types

  • Review

MeSH terms

  • Algorithms
  • Artificial Intelligence*
  • Critical Care
  • Electronic Health Records*
  • Humans
  • Machine Learning