Interplay between bacterial 5'-NAD-RNA decapping hydrolase NudC and DEAD-box RNA helicase CsdA in stress responses

Milda Mickutė; Renatas Krasauskas; Kotryna Kvederavičiūtė; Gytė Tupikaitė; Aleksandr Osipenko; Algirdas Kaupinis; Monika Jazdauskaitė; Raminta Mineikaitė; Mindaugas Valius; Viktoras Masevičius; Giedrius Vilkaitis

doi:10.1128/msystems.00718-23

Interplay between bacterial 5'-NAD-RNA decapping hydrolase NudC and DEAD-box RNA helicase CsdA in stress responses

mSystems. 2023 Oct 26;8(5):e0071823. doi: 10.1128/msystems.00718-23. Epub 2023 Sep 14.

Affiliations

¹ Institute of Biotechnology, Life Sciences Center, Vilnius University , Vilnius, Lithuania.
² Institute of Biochemistry, Life Sciences Center, Vilnius University , Vilnius, Lithuania.
³ Thermo Fisher Scientific Baltics , Vilnius, Lithuania.
⁴ Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University , Vilnius, Lithuania.

Abstract

Non-canonical 5'-caps removing RNA hydrolase NudC, along with stress-responsive RNA helicase CsdA, is crucial for 5'-NAD-RNA decapping and bacterial movement.

Keywords: DEAD-box helicase; NAD-RNA; RNA cap; RNA hydrolase; RNA modification.

MeSH terms

DEAD-box RNA Helicases / genetics
Escherichia coli* / genetics
Hydrolases
NAD*
RNA

Substances

NAD
Hydrolases
DEAD-box RNA Helicases
RNA

Grants and funding

MIP-19-31/Lietuvos Mokslo Taryba (Research Council of Lithuania)