A highly sensitive and reliable tunable diode laser absorption spectroscopy gas detection system with a temperature-pressure compensation algorithm is demonstrated for detecting C H 4 concentrations in near space. Near space generally refers to the airspace 20-100 km away from the ground, where temperature and pressure changes are complex. Since the gas absorption spectrum is easily affected by temperature and pressure, a temperature-pressure compensation algorithm is proposed and used in the C H 4 sensor to improve the detection accuracy of the sensor. First, we measured the basic characteristics of the sensor in the laboratory, such as linearity and long-term stability. Experimental results showed that the linear correlation coefficient R-square can reach 0.999, and the concentration fluctuation of C H 4 is less than 0.17 ppm within 3.5 h. Then the sensor was applied to a research activity in Qinghai Province, China, in September, and the results show that the sensor can effectively monitor the C H 4 concentration in near space.