Endotherapy for Pancreas Divisum

Sumant Inamdar; Gregory A Cote; Dhiraj Yadav

doi:10.1016/j.giec.2023.04.012

Endotherapy for Pancreas Divisum

Gastrointest Endosc Clin N Am. 2023 Oct;33(4):789-805. doi: 10.1016/j.giec.2023.04.012. Epub 2023 May 26.

Authors

Sumant Inamdar¹, Gregory A Cote², Dhiraj Yadav³

Affiliations

¹ Division of Gastroenterology and Hepatology, Department of Medicine, University of Arkansas for Medical Sciences, Shorey Building, 8th Floor, 4301 West Markham Street, Little Rock, AR 72205, USA. Electronic address: sinamdar@uams.edu.
² Division of Gastroenterology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Mail Code L461, Portland, OR, USA.
³ Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburg Medical Center, 200 Lothrop Street, M2, C-wing, Pittsburgh, PA 15213, USA.

PMID: 37709411
DOI: 10.1016/j.giec.2023.04.012

Abstract

Pancreas divisum (PD) is a common anatomic variant of the pancreatic duct. Causal association between PD and pancreatitis has been debated for many years. Minor papilla sphincterotomy (miES) is offered in clinical practice to patients with idiopathic acute recurrent pancreatitis (iRAP) and PD. However, available data originate mainly from observational studies with many limitations. An ongoing international, multicenter, sham-controlled trial is evaluating the efficacy of miES in iRAP and PD. Endoscopic therapy for pain relief has limited to no benefit in patients with chronic abdominal pain or chronic pancreatitis who have PD and is not recommended.

Keywords: Minor papilla intervention; Minor sphincterotomy; Pancreatic divisum.

Publication types

Review

MeSH terms

Abdominal Pain / etiology
Biliary Tract*
Humans
Multicenter Studies as Topic
Pancreas Divisum*
Pancreatitis, Chronic* / complications
Pancreatitis, Chronic* / surgery

Grants and funding

U01 DK116743/DK/NIDDK NIH HHS/United States