Tumour-promoting effect of chilli extract in BALB/c mice

Int J Cancer. 1986 Nov 15;38(5):689-95. doi: 10.1002/ijc.2910380512.


In 50% of BALB/c mice pretreated with atropine, tongue tumours were induced by fortnightly application of DMN-OAc (2 mg/kg) on the tongue. When DMN-OAc + TPA was used for the initiation-promotion protocol, tumours were observed on the tongue, the site of application, in only 10% of animals. In the same group, stomach tumours were obtained in 63% of mice, denoting that initiation-promotion could be successfully used to induce stomach tumours. Using a protocol of DMN-OAc + chilli as a promoter, we observed induction of stomach tumours. The promoter effect of chilli extract was also seen in the BHC-induced hepato-carcinogenesis system. It thus appears that, in BALB/c mice, chilli acts as a promoter in stomach and liver carcinogenesis.

MeSH terms

  • Administration, Topical
  • Animals
  • Atropine / pharmacology
  • Capsaicin / toxicity*
  • Carcinoma, Squamous Cell / chemically induced
  • Cocarcinogenesis*
  • Condiments / toxicity*
  • Female
  • Male
  • Mice
  • Mice, Inbred BALB C*
  • Plant Extracts / toxicity*
  • Stomach Neoplasms / chemically induced
  • Tongue Neoplasms / chemically induced


  • Plant Extracts
  • Atropine
  • Capsaicin