Histone modification: Biomarkers and potential therapies in colorectal cancer

Ann Hum Genet. 2023 Nov;87(6):274-284. doi: 10.1111/ahg.12528. Epub 2023 Sep 15.


The complex mechanism of colorectal cancer development is closely associated with epigenetic modifications and is caused by overexpression and/or inactivation of oncogenes. Histone modifying enzymes catalyze histone modifications to alter gene expression, which plays a crucial role in the development and progression of colorectal cancer. Currently, there is more frequent study on histone acetylation, methylation, and phosphorylation, and their mechanisms in colorectal cancer development are clearer. This article elaborates on the role of histone modification in epigenetics in colorectal cancer development and discusses recent advances in using it as biomarkers and therapeutic targets for the treatment of colorectal cancer. The review aims to demonstrate the significant role of histone modification as a new therapeutic target in colorectal cancer and provides insights into the novel diagnostic and therapeutic options it offers.

Keywords: biomarkers; colorectal cancer; drug targets; epigenetics; histone modifications.

Publication types

  • Review