Individualizing Breast Cancer Risk Assessment in Clinical Practice

Amy E Cyr; Kaitlyn Kennard

doi:10.1016/j.soc.2023.05.013

Individualizing Breast Cancer Risk Assessment in Clinical Practice

Surg Oncol Clin N Am. 2023 Oct;32(4):647-661. doi: 10.1016/j.soc.2023.05.013. Epub 2023 Jul 6.

Authors

Amy E Cyr¹, Kaitlyn Kennard²

Affiliations

¹ Department of Medicine, Washington University, Box 8056, 660 South Euclid Avenue, Saint Louis, MO 63110, USA. Electronic address: amycyr@wustl.edu.
² Department of Surgery, Washington University, Box 8051, 660 South Euclid Avenue, Saint louis, MO 63110, USA.

PMID: 37714634
DOI: 10.1016/j.soc.2023.05.013

Abstract

Multiple tools exist to assess a patient's breast cancer risk. The choice of risk model depends on the patient's risk factors and how the calculation will impact care. High-risk patients-those with a lifetime breast cancer risk of ≥20%-are, for instance, eligible for supplemental screening with breast magnetic resonance imaging. Those with an elevated short-term breast cancer risk (frequently defined as a 5-year risk ≥1.66%) should be offered endocrine prophylaxis. High-risk patients should also receive guidance on modification of lifestyle factors that affect breast cancer risk.

Keywords: Breast cancer risk; High risk; Risk assessment; Risk factors; Risk models; Risk reduction; Screening.

Publication types

Review

MeSH terms

Breast Neoplasms* / diagnosis
Female
Humans
Risk Assessment
Risk Factors