Double hit - A case in point for dual seropositivity to AQP4 and MOG antibodies

Kshiteeja Jain; M Anita; M Netravathi

doi:10.1016/j.jneuroim.2023.578198

Double hit - A case in point for dual seropositivity to AQP4 and MOG antibodies

J Neuroimmunol. 2023 Oct 15:383:578198. doi: 10.1016/j.jneuroim.2023.578198. Epub 2023 Sep 12.

Authors

Kshiteeja Jain¹, M Anita², M Netravathi³

Affiliations

¹ Department of Neurology, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India.
² Department of Neuropathology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.
³ Department of Neurology, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India. Electronic address: sundernetra@yahoo.co.in.

PMID: 37716133
DOI: 10.1016/j.jneuroim.2023.578198

Abstract

AQP4-IgG NMOSD (anti-aquaporin-4 neuromyelitis optica spectrum disorder) and MOGAD (myelin oligodendrocyte glycoprotein antibody associated disease) are unique disorders among themselves, with rare reports of dual seropositivity being described. Evaluation with cell-based assays reduces the incidence of false positivity. The clinical features of these cases may either have a dominant phenotype or may evolve into one subsequently. We describe a young girl aged 18-year-old who presented with longitudinally extensive transverse myelitis and dual seropositivity to both AQP4 and MOG antibodies.

Keywords: AQP4; Dual; LETM; MOG; Myelitis; NMOSD; Seropositive.