Whole Gamma Imaging: Challenges and Opportunities

PET Clin. 2024 Jan;19(1):83-93. doi: 10.1016/j.cpet.2023.08.003. Epub 2023 Sep 15.


Compton imaging has been recognized as a possible nuclear medicine imaging method following the establishment of SPECT and PET. Whole gamma imaging (WGI), a combination of PET and Compton imaging, could be the first practical method to bring out the potential of Compton imaging in nuclear medicine. With the use of such positron emitters as 89Zr and 44Sc, WGI may enable highly sensitive imaging of antibody drugs for early tumor detection and quantitative hypoxia imaging for effective tumor treatment. Some of these concepts have been demonstrated preliminarily in physics experiments and small animal imaging tests with a developed WGI prototype.

Keywords: Antibody; Compton camera; Multiple myeloma; PET; Positronium; WGI.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Neoplasms* / diagnostic imaging
  • Nuclear Medicine*
  • Radionuclide Imaging
  • Radiopharmaceuticals
  • Tomography, Emission-Computed, Single-Photon / methods


  • Radiopharmaceuticals