Lifestyle and host determinants of antitumor immunity and cancer health disparities

Trends Cancer. 2023 Dec;9(12):1019-1040. doi: 10.1016/j.trecan.2023.08.007. Epub 2023 Sep 16.


Lifestyle factors exert profound effects on host physiology and immunology. Disparities in cancer outcomes persist as a complex and multifaceted challenge, necessitating a comprehensive understanding of the interplay between host environment and antitumor immune responses. Determinants of health - such as obesity, diet, exercise, stress, or sleep disruption - have the potential for modification, yet some exert long-lasting effects and may challenge the notion of complete reversibility. Herein we review intersectional considerations of lifestyle immunity and the impact on tumor immunology and disparities in cancer outcomes, with a focus on obesity.

Keywords: cancer health disparities; immunotherapy; intersectionality; lifestyle immunity; tumor immunology.

Publication types

  • Review

MeSH terms

  • Diet
  • Exercise
  • Humans
  • Life Style
  • Neoplasms* / epidemiology
  • Obesity / epidemiology