Manipulating the Destiny of Wild Populations Using CRISPR

Annu Rev Genet. 2023 Nov 27:57:361-390. doi: 10.1146/annurev-genet-031623-105059. Epub 2023 Sep 18.


Genetic biocontrol aims to suppress or modify populations of species to protect public health, agriculture, and biodiversity. Advancements in genome engineering technologies have fueled a surge in research in this field, with one gene editing technology, CRISPR, leading the charge. This review focuses on the current state of CRISPR technologies for genetic biocontrol of pests and highlights the progress and ongoing challenges of using these approaches.

Keywords: CRISPR; gene drive; genetic biocontrol; homing; population modification; population suppression.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • CRISPR-Cas Systems* / genetics
  • Clustered Regularly Interspaced Short Palindromic Repeats* / genetics
  • Gene Editing
  • Genome