Exceptional Response to Olaparib: A Case Report of Metastatic Esophageal Squamous Cell Carcinoma in a Patient With Fanconi Anemia, Germline FANCA Mutation, and Somatic BRCA2 Mutations

Lucy R Haggstrom; Kathy Tucker; Rachel Williams; Adam Nelson; Rebecca Walsh; Daniel Brungs; Morteza Aghmesheh

doi:10.1200/PO.23.00221

Exceptional Response to Olaparib: A Case Report of Metastatic Esophageal Squamous Cell Carcinoma in a Patient With Fanconi Anemia, Germline FANCA Mutation, and Somatic BRCA2 Mutations

JCO Precis Oncol. 2023 Sep:7:e2300221. doi: 10.1200/PO.23.00221.

Authors

Lucy R Haggstrom^{1

2}, Kathy Tucker^{2

3

4}, Rachel Williams^{2

3

4}, Adam Nelson⁵, Rebecca Walsh⁶, Daniel Brungs^{1

7}, Morteza Aghmesheh^{1

2

7}

Affiliations

¹ Illawarra Cancer Care Centre, Wollongong Hospital, Wollongong, NSW, Australia.
² Nelune Cancer Care Centre, Prince of Wales Hospital, Randwick, NSW, Australia.
³ School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Kensington, NSW, Australia.
⁴ Hereditary Cancer Centre, Prince of Wales Hospital, Randwick, NSW, Australia.
⁵ Sydney Children's Hospital, Randwick, NSW, Australia.
⁶ NSW Health Pathology Genetics Laboratory, Randwick, NSW, Australia.
⁷ Graduate School of Medicine, University of Wollongong, Wollongong, NSW, Australia.

PMID: 37725782
DOI: 10.1200/PO.23.00221

No abstract available

Publication types

Case Reports

MeSH terms

BRCA2 Protein / genetics
Esophageal Neoplasms* / drug therapy
Esophageal Neoplasms* / genetics
Esophageal Squamous Cell Carcinoma* / drug therapy
Esophageal Squamous Cell Carcinoma* / genetics
Fanconi Anemia Complementation Group A Protein
Fanconi Anemia* / complications
Fanconi Anemia* / drug therapy
Fanconi Anemia* / genetics
Germ Cells
Humans
Mutation
Phthalazines
Piperazines

Substances

Fanconi Anemia Complementation Group A Protein
BRCA2 Protein
olaparib
Phthalazines
Piperazines
FANCA protein, human
BRCA2 protein, human