Current Neurostimulation Therapies for Chronic Pain Conditions

Curr Pain Headache Rep. 2023 Sep 20. doi: 10.1007/s11916-023-01168-5. Online ahead of print.


Purpose of review: Neurostimulation treatment options have become more commonly used for chronic pain conditions refractory to these options. In this review, we characterize current neurostimulation therapies for chronic pain conditions and provide an analysis of their effectiveness and clinical adoption. This manuscript will inform clinicians of treatment options for chronic pain.

Recent findings: Non-invasive neurostimulation includes transcranial direct current stimulation and repetitive transcranial magnetic stimulation, while more invasive options include spinal cord stimulation (SCS), peripheral nerve stimulation (PNS), dorsal root ganglion stimulation, motor cortex stimulation, and deep brain stimulation. Developments in transcranial direct current stimulation, repetitive transcranial magnetic stimulation, spinal cord stimulation, and peripheral nerve stimulation render these modalities most promising for the alleviating chronic pain. Neurostimulation for chronic pain involves non-invasive and invasive modalities with varying efficacy. Well-designed randomized controlled trials are required to delineate the outcomes of neurostimulatory modalities more precisely.

Keywords: Deep brain stimulation; Dorsal root ganglion stimulation; Neuromodulation; Peripheral nerve stimulation; Spinal cord stimulation.

Publication types

  • Review