Topical flucytosine therapy for chronic recurrent Candida tropicalis infections

J Reprod Med. 1986 Sep;31(9):821-4.


Forty-one women with a culture-proven diagnosis of Candida tropicalis were treated with miconazole or clotrimazole cream topically or ketoconazole orally. In 15 patients the infection recurred or remained uncured. Five-fluorocytosine was compounded into a topical vaginal cream and applied nightly for seven nights. In 14 of the 15 patients the infection disappeared. One patient remains uncured.

MeSH terms

  • Candidiasis / drug therapy*
  • Chronic Disease
  • Female
  • Flucytosine / administration & dosage*
  • Flucytosine / therapeutic use
  • Humans
  • Recurrence
  • Vaginal Creams, Foams, and Jellies
  • Vaginal Diseases / drug therapy*


  • Vaginal Creams, Foams, and Jellies
  • Flucytosine