Multiparametric MRI for Staging of Bowel Inflammatory Activity in Crohn's Disease with MUSE-IVIM and DCE-MRI: A Preliminary Study

Liangqiang Mao; Yan Li; Bota Cui; Lin Lu; Weiqiang Dou; Dmytro Pylypenko; Jianguo Zhu; Haige Li

doi:10.1016/j.acra.2023.08.028

Multiparametric MRI for Staging of Bowel Inflammatory Activity in Crohn's Disease with MUSE-IVIM and DCE-MRI: A Preliminary Study

Acad Radiol. 2024 Mar;31(3):880-888. doi: 10.1016/j.acra.2023.08.028. Epub 2023 Sep 18.

Authors

Liangqiang Mao¹, Yan Li¹, Bota Cui², Lin Lu³, Weiqiang Dou⁴, Dmytro Pylypenko⁴, Jianguo Zhu⁵, Haige Li¹

Affiliations

¹ Department of Radiology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, PR China.
² Department of Gastroenterology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, PR China.
³ Department of Radiology, Columbia University Medical Center, New York, New York.
⁴ GE Healthcare, MR Research China, Beijing, PR China.
⁵ Department of Radiology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, PR China. Electronic address: zhujianguo@njmu.edu.cn.

PMID: 37730492
DOI: 10.1016/j.acra.2023.08.028

Abstract

Rationale and objectives: To investigate if the combination of multishot diffusion imaging-based multiplexed sensitivity encoding intravoxel incoherent motion (MUSE-IVIM) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is feasible for staging Crohn's disease (CD) activity.

Materials and methods: A total of 65 CD patients were enrolled and analyzed in this retrospective study. The simplified endoscopic score for Crohn's disease (SES-CD) and magnetic resonance index of activity (MaRIA) were used as the reference. The MUSE-IVIM and DCE-MRI data were acquired at 3.0-T MRI scanner and processed by two radiologists. Three MUSE-IVIM parameters: fast apparent diffusion coefficient (ADC_fast), slow apparent diffusion coefficient (ADC_slow), and the fractional perfusion (Fraction of ADC_fast), as well as four DCE-MRI parameters: volume transfer constant (K^trans), rate constant (K_ep), extravascular extracellular volume fraction (V_e), and plasma volume fraction (V_p) were generated. Intraclass correlation coefficient (ICC), non-parametric test (Kruskal-Wallis H and Mann-Whitney U), logistic regression, receiver operating characteristic analysis, Delong test, and Spearman's correlation test were performed.

Results: According to SES-CD, 116 ileocolonic segments with CD lesions were identified as: inactive, mild, and moderate to severe. With multivariable logistic regression analysis, ADC_fast (p < 0.001), Fraction of ADC_fast (p = 0.005), K^trans (p < 0.001) and K_ep (p = 0.003) were identified as significant factors for differentiating among the three groups. Binary logistic analyses identified ADC_fast (p = 0.001), K^trans (p = 0.014), and K_ep (p = 0.029) as independent predictors for the active status. The combination of ADC_fast, K^trans, and K_ep performed better than MaRIA score (p = 0.028), for differentiating inactive and active status. MaRIA score was positively correlated with ADC_fast (p < 0.001), K^trans (p < 0.001), K_ep (p < 0.001), and V_e (p = 0.001), however, negatively correlated with Fraction of ADC_fast (p < 0.001).

Conclusion: The combination of MUSE-IVIM and DCE-MRI has been demonstrated to accurately stage inflammatory activity in CD.

Keywords: Crohn's disease; Dynamic contrast-enhanced; Inflammatory activity; Intravoxel incoherent motion; Multiplexed sensitivity encoding.

MeSH terms

Alprostadil
Contrast Media
Crohn Disease* / diagnostic imaging
Diffusion Magnetic Resonance Imaging / methods
Humans
Magnetic Resonance Imaging / methods
Multiparametric Magnetic Resonance Imaging*
Retrospective Studies

Substances

Alprostadil
Contrast Media