Mediastinal Presentation of Testicular Embryonal Carcinoma

S D Med. 2023 Aug;76(8):342-344.


Testicular embryonal carcinoma is a type of nonseminomatous germ cell tumor (NSGCT) that commonly presents with scrotal swelling due to testicular mass. About half of patients with NSGCTs will present with metastases at initial diagnosis. Rarely, testicular embryonal carcinoma can present primarily in the mediastinum. Treatment is well-studied and effective: chemotherapy with bleomycin, etoposide, and cisplatin. Post-chemotherapy retroperitoneal lymph node dissection (RPLND) is common adjuvant therapy. In this report we present a case of testicular embryonal carcinoma in a 32-year-old Caucasian man. The rarity of the case resides in its presentation: supraclavicular lymphadenopathy and no testicular mass on palpation or scrotal ultrasound.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Carcinoma, Embryonal* / diagnosis
  • Etoposide
  • Humans
  • Male
  • Mediastinum
  • Neoplasms, Germ Cell and Embryonal* / diagnosis
  • Neoplasms, Germ Cell and Embryonal* / therapy
  • Testicular Neoplasms* / diagnosis
  • Testicular Neoplasms* / therapy


  • Etoposide