Synthesis of pyridone derivatives using 2D rod like bifunctional Fe based MOF and CuO nanocomposites as a novel heterogeneous catalyst

Negar Hoot; Enayatollah Sheikhhosseini; Sayed Ali Ahmadi; Mahdieh Ghazizadeh; Moslem Malekshahi; Mahdieh Yahyazadehfar

doi:10.1038/s41598-023-43045-6

Synthesis of pyridone derivatives using 2D rod like bifunctional Fe based MOF and CuO nanocomposites as a novel heterogeneous catalyst

Sci Rep. 2023 Sep 21;13(1):15753. doi: 10.1038/s41598-023-43045-6.

Authors

Negar Hoot¹, Enayatollah Sheikhhosseini², Sayed Ali Ahmadi¹, Mahdieh Ghazizadeh¹, Moslem Malekshahi^{1

3}, Mahdieh Yahyazadehfar¹

Affiliations

¹ Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran.
² Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran. sheikhhosseiny@gmail.com.
³ Department of Physics, Kerman Branch, Islamic Azad University, Kerman, Iran.

Abstract

In this study, a new and efficient Rod-like bifunctional Fe-based MOF@CuO nanocomposites (RL BF Fe-based MOF@CuO NC) were synthesized as new and efficient heterogeneous catalyst through a simple method from easily available 1,3,5-benzenetricarbocylic acid linker, nitrate ferric as a source of iron and copper oxide (CuO) nanoparticles under microwave irradiation. The synthesized nanocatalysts were characterized with different techniques such as Brunauer-Emmett-Teller (BET), energy dispersive spectroscopy (EDS), field emission scanning electron microscopy (FE-SEM), mapping, transmission electron microscopy (TEM), X-ray diffraction (XRD), vibrating sample magnetometer (VSM), thermogravimetric analysis (TGA) and Fourier transform infrared spectroscopy (FT-IR). The RL BF Fe-based MOF@CuO NC had relatively high specific surface area (203 m² g^-1) while exhibiting superparamagnetic properties. The catalytic activity of RL BF Fe-based MOF@CuO NC was explored in a facile and green methodology to prepare diverse N‑amino-2-pyridones by one-pot four component reactions comprising aromatic aldehyde, malononitrile, methyl cyanoacetate and hydrazine hydrate within mild and solvent-free conditions. This protocol enjoys features like providing the final products during low reaction times in excellent yields under solvent-free conditions. The use of easily available and inexpensive reactants for the synthesis of the catalyst, environmental compatibility, low catalyst loading, fast and clean work-up and reusability of catalyst for several cycles with consistent activity are counted as the outstanding features of this procedure.